The Unfolded Protein Response: Methods and Protocols by Roberto Pérez-Torrado (Editor)

Publisher: BIOLOGY

Availability: In Stock
SKU: 49409
Number of Pages: 344

Rs.760.00

Rs.1,050.00

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"The Unfolded Protein Response: Methods and Protocols," edited by Roberto Pérez-Torrado, provides a comprehensive exploration of the unfolded protein response (UPR), a crucial cellular mechanism that ensures protein homeostasis in eukaryotic cells. This detailed volume compiles cutting-edge methodologies and protocols essential for studying various aspects of UPR activation, regulation, and its implications in cellular physiology and disease. The book begins with an overview of the UPR signaling pathways, detailing the molecular mechanisms involved in sensing and responding to protein folding stress within the endoplasmic reticulum (ER). It then delves into experimental techniques, offering step-by-step protocols for researchers to investigate UPR activation, monitor ER stress markers, and analyze downstream cellular responses using advanced molecular biology, biochemistry, and imaging approaches.

Furthermore, this book addresses the diverse applications of UPR research in both basic and translational science, highlighting its relevance in understanding diseases such as neurodegeneration, diabetes, and cancer. Each chapter provides clear methodologies, troubleshooting tips, and insightful discussions on the interpretation of experimental results, making it an indispensable resource for scientists and students interested in molecular cell biology, protein quality control mechanisms, and therapeutic targeting of ER stress pathways.

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