Pharmaceutical Formulation Development of Peptides and Proteins

Pharmaceutical Formulation Development of Peptides and Proteins, edited by Lars Hovgaard and Sven Frokjaer, is an authoritative text focusing on the complexities of formulating peptide and protein-based pharmaceutical products. As biotechnology advances, peptides and proteins are increasingly used as therapeutic agents, making the development of stable, effective dosage forms crucial. This book provides an in-depth exploration of the various challenges and strategies involved in formulating these biologically active compounds, such as maintaining stability, solubility, and bioactivity. The editors and contributing experts discuss a wide range of topics, including formulation strategies, delivery systems, the impact of excipients, and the regulatory landscape. The book is an essential resource for professionals in the pharmaceutical industry, particularly those working in biopharmaceuticals, as well as researchers and students with an interest in drug formulation and development.

Key Points:

1. Focus on Biopharmaceuticals: Provides a detailed examination of peptide and protein-based drugs, which are increasingly used in modern therapeutics.

2. Formulation Challenges: Discusses the key challenges faced in formulating peptides and proteins, including stability, solubility, and maintaining biological activity.

3. Delivery Systems: Covers the development of advanced drug delivery systems tailored for peptides and proteins, such as injectable, oral, and transdermal systems.

4. Excipients and Additives: Explores the role of excipients in peptide and protein formulations, including stabilizers, buffers, and preservatives that improve product performance.

5. Stability and Shelf-Life: Emphasizes strategies to enhance the stability of biologic drugs, preventing degradation and ensuring long shelf-life.

6. Bioavailability Considerations: Examines how to enhance the bioavailability of peptides and proteins, addressing issues such as absorption and targeted delivery.

7. Regulatory Requirements: Outlines the regulatory challenges and requirements for peptide and protein-based drugs, including clinical trials and manufacturing standards.

8. Innovative Formulation Approaches: Discusses novel technologies and methodologies in the formulation and development of biologics, including encapsulation and nanoparticle systems.

9. Case Studies and Applications: Includes real-world examples of peptide and protein drug formulations, providing practical insights into the application of theoretical concepts.

10. Essential for Industry Professionals: A crucial resource for pharmaceutical professionals, researchers, and students involved in the development of peptide and protein-based therapies.

Conclusion: Pharmaceutical Formulation Development of Peptides and Proteins is an invaluable resource that provides a comprehensive and detailed guide to the formulation of biologic drugs. By addressing both theoretical and practical aspects of drug development, this book equips professionals with the necessary knowledge to overcome the unique challenges of working with peptides and proteins. It is an essential text for anyone involved in the biopharmaceutical industry or interested in the future of protein-based therapeutics.

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Writer                 ✤               Lars Hovgaard (Editor), Sven Frokjaer (Editor)