Concepts and Models for Drug Permeability Studies By Bruno Sarmento

Concepts and Models for Drug Permeability Studies by Bruno Sarmento provides an in-depth exploration of the various methodologies and theoretical frameworks used to evaluate drug permeability. This book covers the fundamental concepts necessary to understand drug absorption and distribution within biological systems. It delves into both traditional and innovative models, examining their applications and limitations in pharmaceutical research. The work is essential for professionals in drug development, offering insights into the practicalities of predicting drug behavior in human tissues.

Key Points

1. Fundamental Concepts of Drug Permeability Discusses the basic principles of drug permeability, including diffusion, transport mechanisms, and factors affecting drug absorption.

2. In Vitro Models Covers cell-based assays and artificial membranes used to simulate drug permeability and predict in vivo behavior.

3. In Vivo Models Examines animal models and human studies that provide data on drug permeability in real biological systems.

4. Computational Models Explores the use of computer simulations and algorithms to predict drug permeability and optimize drug design.

5. Role of Drug Physicochemical Properties Analyzes how molecular size, lipophilicity, and ionization affect drug permeability.

6. Transporter Proteins and Their Impact Details the function of transporter proteins in drug absorption and the significance of efflux and influx mechanisms.

7. Barriers to Drug Permeability Identifies physiological barriers, such as the blood-brain barrier, and their implications for drug delivery.

8. Enhancing Drug Permeability Discusses techniques to improve drug permeability, including chemical modifications and formulation strategies.

9. Regulatory Perspectives Provides an overview of regulatory guidelines and requirements for permeability studies in drug development.

10. Case Studies and Applications Presents real-world examples of how drug permeability studies have influenced the development and approval of pharmaceuticals.

By combining theoretical insights with practical applications, Concepts and Models for Drug Permeability Studies by Bruno Sarmento serves as a comprehensive guide for researchers and professionals in the field. The book's detailed examination of various models and methodologies offers valuable knowledge for enhancing drug design and optimizing therapeutic efficacy.

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Writer                 ✤            Bruno Sarmento