Cancer Cytogenetics: Methods and Protocols by John Swansbury (Editor)

Cancer Cytogenetics: Methods and Protocols (Methods in Molecular Biology, Vol. 220)
Editor: John Swansbury

Introduction

Cancer Cytogenetics: Methods and Protocols is part of the Methods in Molecular Biology series, offering a detailed guide to the latest techniques in cancer cytogenetics. Edited by John Swansbury, the book provides a step-by-step approach to studying chromosomal abnormalities associated with cancer. It covers both classical cytogenetic methods and modern molecular techniques, including fluorescence in situ hybridization (FISH), comparative genomic hybridization (CGH), and spectral karyotyping (SKY). This book is designed to help researchers and clinicians understand the genetic mechanisms underlying cancer and apply these insights to diagnosis and therapy.

Key Points

• Provides detailed protocols for classical and modern cytogenetic techniques.
• Explores fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH).
• Covers spectral karyotyping (SKY) and multicolor FISH for analyzing complex chromosomal changes.
• Discusses methods for preparing and analyzing metaphase spreads.
• Includes guidance on data interpretation and troubleshooting.
• Offers insight into the role of cytogenetics in cancer diagnosis and prognosis.
• Features contributions from leading experts in the field.

Why Read This Book

• Essential for understanding the genetic basis of cancer.
• Combines classical and modern techniques in one resource.
• Provides practical, step-by-step protocols with clear instructions.
• Valuable for researchers, cytogeneticists, and oncologists.
• Enhances understanding of how chromosomal changes influence cancer progression and treatment.

Conclusion

Cancer Cytogenetics: Methods and Protocols is a valuable reference for scientists and clinicians involved in cancer research and diagnosis. Its comprehensive coverage of cytogenetic techniques makes it an indispensable resource for advancing cancer genetics research.